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In 1864, Adolphus Busch went to work at a brewery owned by his father-in-law, Eberhard Anheuser. 15 years later, the company changed it's name to Anheuser-Busch. Fueled by the popularity of it's top selling product, Budweiser, the brewery would grow to become the biggest in the nation. It didn't get to be #1 by accident.
Several factors helped the St. Louis based beer maker become popular. Adolphus Busch made use of pasteurization, the practice of introducing heat to the brewing process. The pasteurization of beer helped destroy micro-organisms within the beer, which gave it a longer shelf life. Combined with a fleet of 850 refrigerated rail cars, Busch was able to ship his beer great distances from the St. Louis brewery.